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Article

Effects of genetic variation on chromatin structure and the transcriptional machinery: analysis of the IL6 gene locus.

Genes and immunity - 1 Oct 2012

Smith A J P, Zheng D, Palmen J, Pang D X, Woo P, Humphries S E

Abstract excerpt

The presence of functional regulatory polymorphism at the interleukin 6 (IL6) locus is uncertain, with many conflicting in vitro findings. To examine the in vivo effect of the three putative functional IL6 promoter variants, -174G>C, -572G>C and -6331T>C, two complementary techniques, allele-specific chromatin immunoprecipitation and allele-specific formaldehyde-assisted isolation of regulatory elements, were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22895491
DOI: 10.1038/gene.2012.32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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