Article
The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter.
Molecular nutrition & food research - 1 Feb 2016
Ma Yiyi, Smith Caren E, Lai Chao-Qiang, Irvin Marguerite R, Parnell Laurence D, Lee Yu-Chi, Pham Lucia D, Aslibekyan Stella, Claas Steven A, Tsai Michael Y, Borecki Ingrid B, Kabagambe Edmond K, Ordovás José M, Absher Devin M, Arnett Donna K
Abstract excerpt
SCOPE: Omega-3 PUFAs (n-3 PUFAs) reduce IL-6 gene expression, but their effects on transcription regulatory mechanisms are unknown. We aimed to conduct an integrated analysis with both population and in vitro studies to systematically explore the relationships among n-3 PUFA, DNA methylation, single nucleotide polymorphisms (SNPs), gene expression, and protein concentration of IL6. METHODS AND RESULTS: Using data...
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