Article
Schwann-Cell-Specific Deletion of Phosphatidylinositol 4-Kinase Alpha Causes Aberrant Myelination.
Cell reports - 5 Jun 2018
Alvarez-Prats Alejandro, Bjelobaba Ivana, Aldworth Zane, Baba Takashi, Abebe Daniel, Kim Yeun Ju, Stojilkovic Stanko S, Stopfer Mark, Balla Tamas
Abstract excerpt
Active membrane remodeling during myelination relies on phospholipid synthesis and membrane polarization, both of which are known to depend on inositol phospholipids. Here, we show that sciatic nerves of mice lacking phosphatidylinositol 4-kinase alpha (PI4KA) in Schwann cells (SCs) show substantially reduced myelin thickness with grave consequences on nerve conductivity and motor functions. Surprisingly,...
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