Article
Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.
European journal of immunology - 1 Jul 2004
Ellmerich Stephan, Takacs Katalin, Mycko Marcin, Waldner Hanspeter, Wahid Faisal, Boyton Rosemary J, Smith Paul A, Amor Sandra, Baker David, Hafler David A, Kuchroo Vijay K, Altmann Daniel M
Abstract excerpt
While EAE has been an invaluable model for the immunopathogenesis of multiple sclerosis, it has sometimes been difficult to bridge the gap between findings and therapies in the rodent models and the cellular and molecular interactions that can be studied in the human disease. Humanized transgenic models offer a means of achieving this, through the expression of disease-implicated HLA class II molecules,...
Topics
- Animals
- Cells, Cultured
- Disease Models, Animal
- Epitopes
- Female
- Humans
- Male
- Mice
- Mice, Transgenic
- Multiple Sclerosis
- Myelin Basic Protein
- Phenotype
- Receptors, Antigen, T-Cell