<i>wasted away</i> , a <i>Drosophila</i> mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death

Abstract excerpt

To identify genes required for maintaining neuronal viability, we screened our collection of Drosophila temperature-sensitive paralytic mutants for those exhibiting shortened lifespan and neurodegeneration. Here, we describe the characterization of wasted away (wstd), a recessive, hypomorphic mutation that causes progressive motor impairment, vacuolar neuropathology, and severely reduced lifespan. We demonstrate...

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