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Article

High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis.

PloS one - 1 Jan 2012

Cao Yali, Yang Jiajin, Colby Kerry, Hogan Susan L, Hu Yichun, Jennette Caroline E, Berg Elisabeth A, Zhang Youkang, Jennette J Charles, Falk Ronald J, Preston Gloria A

Abstract excerpt

Consequences of expression of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gain-of-function variant were evaluated in leukocytes from patients with anti-neutrophil cytoplasmic autoantibody (ANCA) disease. The frequency of the gain-of-function allele within the Caucasian patient cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22880107
DOI: 10.1371/journal.pone.0042783
PMCID: PMC3411839

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22880107-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis.PMID 22880107Read ↗

Regulation of T Cell Signaling and Immune Responses by PTPN22.Semantic proximity Read ↗

Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.Semantic proximity Read ↗

Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.Semantic proximity Read ↗

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.Semantic proximity Read ↗

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.Semantic proximity Read ↗

PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.Semantic proximity Read ↗

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.Semantic proximity Read ↗

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Semantic proximity Read ↗

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.Semantic proximity Read ↗

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.Semantic proximity Read ↗

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.Semantic proximity Read ↗

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