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Article

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.

PloS one - 1 Jan 2012

Dueñas Marta, Santos Mirentxu, Aranda Juan F, Bielza Concha, Martínez-Cruz Ana B, Lorz Corina, Taron Miquel, Ciruelos Eva M, Rodríguez-Peralto José L, Martín Miguel, Larrañaga Pedro, Dahabreh Jubrail, Stathopoulos George P, Rosell Rafael, Paramio Jesús M, García-Escudero Ramón

Abstract excerpt

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p5...

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Identifiers

PMID: 22880004
DOI: 10.1371/journal.pone.0042494
PMCID: PMC3413665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22880004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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