Article
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
PloS one - 1 Jan 2009
Gibbons Don L, Lin Wei, Creighton Chad J, Zheng Shuling, Berel Dror, Yang Yanan, Raso Maria Gabriela, Liu Diane D, Wistuba Ignacio I, Lozano Guillermina, Kurie Jonathan M
Abstract excerpt
BACKGROUND: Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. METHODOLOGY/PRINCIPAL FINDINGS: Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that...
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