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Article

Association of 5'UTR polymorphism of secretory phospholipase A2 group IIA (PLA2G2A) gene with prostate cancer metastasis.

Gene - 5 Jun 2020

Ozturk Kaan, Onal Meltem Selen, Efiloglu Ozgur, Nikerel Emrah, Yildirim Asif, Telci Dilek

Abstract excerpt

Phospholipase A2 (PLA2) enzymes are small lipolytic hydrolases that can regulate immune responses through generation of Arachidonic Acid (AA), a precursor molecule of lipid mediators like prostaglandins, leukotrienes and thromboxanes. One of the family members of PLA2, secretory Phospholipase A2 Group IIA (PLA2G2A), was associated with different types of malignancies including prostate cancer. Elevated serum...

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PMID: 32179174
DOI: 10.1016/j.gene.2020.144589

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