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Article

Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by μCT and Histomorphometry.

Current osteoporosis reports - 1 Apr 2018

Rowe David W, Adams Douglas J, Hong Seung-Hyun, Zhang Caibin, Shin Dong-Guk, Renata Rydzik C, Chen Li, Wu Zhihua, Garland Gaven, Godfrey Dana A, Sundberg John P, Ackert-Bicknell Cheryl

Abstract excerpt

PURPOSE OF REVIEW: The international mouse phenotyping consortium (IMPC) is producing defined gene knockout mouse lines. Here, a phenotyping program is presented that is based on micro-computed tomography (μCT) assessment of distal femur and vertebra. Lines with significant variation undergo a computer-based bone histomorphometric analysis. RECENT FINDINGS: Of the 220 lines examined to date, approximately 15%...

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PMID: 29508144
DOI: 10.1007/s11914-018-0421-4

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