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Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

19 Jul 2019

Abstract excerpt

Prion diseases are a group of incurable neurodegenerative disorders that affect humans and animals via infection with proteinaceous particles called prions. Prions are composed of PrP Sc , a misfolded version of the cellular prion protein (PrP C ). During disease progression, PrP Sc replicates by interacting with PrP C and inducing its conversion to PrP Sc . As PrP Sc accumulates, cellular stress mechanisms are...

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PMID: 31320473
DOI: 10.1074/jbc.ra118.006186

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