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Article

Transcription factor YY1 can control AID-mediated mutagenesis in mice.

European journal of immunology - 1 Feb 2018

Zaprazna Kristina, Basu Arindam, Tom Nikola, Jha Vibha, Hodawadekar Suchita, Radova Lenka, Malcikova Jitka, Tichy Boris, Pospisilova Sarka, Atchison Michael L

Abstract excerpt

Activation-induced cytidine deminase (AID) is crucial for controlling the immunoglobulin (Ig) diversification processes of somatic hypermutation (SHM) and class switch recombination (CSR). AID initiates these processes by deamination of cytosine, ultimately resulting in mutations or double strand DNA breaks needed for SHM and CSR. Levels of AID control mutation rates, and off-target non-Ig gene mutations can...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29080214
DOI: 10.1002/eji.201747065
PMCID: PMC5884117

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