Article
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.
Molecular and cellular biology - 1 Oct 2012
Mathew Sijo, Lu Zhenwei, Palamuttam Riya J, Mernaugh Glenda, Hadziselimovic Arina, Chen Jiang, Bulus Nada, Gewin Leslie S, Voehler Markus, Meves Alexander, Ballestrem Christoph, Fässler Reinhard, Pozzi Ambra, Sanders Charles R, Zent Roy
Abstract excerpt
Loss of β1 integrin expression inhibits renal collecting-system development. Two highly conserved NPXY motifs in the distal β1 tail regulate integrin function by associating with phosphtyrosine binding (PTB) proteins, such as talin and kindlin. Here, we define the roles of these two tyrosines in collecting-system development and delineate the structural determinants of the distal β1 tail using nuclear magnetic...
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