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Article

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

The Journal of cell biology - 2 Apr 2018

Sun Hao, Lagarrigue Frederic, Gingras Alexandre R, Fan Zhichao, Ley Klaus, Ginsberg Mark H

Abstract excerpt

Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes. A proline mutation in the central integrin β3 transmembrane domain (TMD) creates a flexible kink that uncouples the topology of the inner half of the TMD from the outer half. In this study, using leukocyte integrin α4β7, which enables...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29535192
DOI: 10.1083/jcb.201707055
PMCID: PMC5881498

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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