Article
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology - 1 Jun 2020
Crislip G Ryan, Douma Lauren G, Masten Sarah H, Cheng Kit-Yan, Lynch I Jeanette, Johnston Jermaine G, Barral Dominique, Glasford Krystal B, Holzworth Meaghan R, Verlander Jill W, Wingo Charles S, Gumz Michelle L
Abstract excerpt
The renal circadian clock has a major influence on the function of the kidney. Aryl hydrocarbon receptor nuclear translocator-like protein 1 [ARNTL; also known as brain and muscle ARNT-like 1 (BMAL1)] is a core clock protein and transcription factor that regulates the expression of nearly half of all genes. Using male and female kidney-specific cadherin BMAL1 knockout (KS-BMAL1 KO) mice, we examined the role of...
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