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Article

Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate.

The Journal of clinical investigation - 1 Nov 2000

Wharram B L, Goyal M, Gillespie P J, Wiggins J E, Kershaw D B, Holzman L B, Dysko R C, Saunders T L, Samuelson L C, Wiggins R C

Abstract excerpt

Glomerular epithelial protein 1 (GLEPP1) is a receptor tyrosine phosphatase present on the apical cell surface of the glomerular podocyte. The GLEPP1 gene (PTPRO:) was disrupted at an exon coding for the NH(2)-terminal region by gene targeting in embryonic stem cells. Heterozygote mating produced the expected genotypic ratio of 1:2:1, indicating that the Ptpro(-/-) genotype does not lead to embryonic or neonatal...

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Source

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Identifiers

PMID: 11086029
DOI: 10.1172/JCI7236
PMCID: PMC381432

Genes

PTPRO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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