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Article

Therapeutic implications of the mGluR theory of fragile X mental retardation

2 Jun 2005

Abstract excerpt

Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development,...

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Identifiers

PMID: 16098137
DOI: 10.1111/j.1601-183x.2005.00135.x

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