Human Immunodeficiency Virus Gag and protease: partners in resistance.

doi:10.1186/1742-4690-9-63

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Article

Human Immunodeficiency Virus Gag and protease: partners in resistance.

Retrovirology - 6 Aug 2012

Fun Axel, Wensing Annemarie M J, Verheyen Jens, Nijhuis Monique

Abstract excerpt

Human Immunodeficiency Virus (HIV) maturation plays an essential role in the viral life cycle by enabling the generation of mature infectious virus particles through proteolytic processing of the viral Gag and GagPol precursor proteins. An impaired polyprotein processing results in the production of non-infectious virus particles. Consequently, particle maturation is an excellent drug target as exemplified by...

Topics

Binding Sites
Drug Resistance, Viral
Evolution, Molecular
Genetic Variation
HIV Infections
HIV Protease
HIV Protease Inhibitors
HIV-1
Humans
Mutation
Selection, Genetic
Virus Replication
gag Gene Products, Human Immunodeficiency Virus
pol Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 22867298
DOI: 10.1186/1742-4690-9-63
PMCID: PMC3422997

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