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Article

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

Retrovirology - 24 Aug 2011

Fun Axel, van Maarseveen Noortje M, Pokorná Jana, Maas Renée Em, Schipper Pauline J, Konvalinka Jan, Nijhuis Monique

Abstract excerpt

BACKGROUND: Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles. This rearrangement is triggered by the ordered cleavage of the precursor Gag polyproteins into their functional counterparts by the viral enzyme protease. In contrast to protease inhibitors,...

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Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21864346
DOI: 10.1186/1742-4690-8-70
PMCID: PMC3184055

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HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.PMID 21864346Read ↗

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