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Article

Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

The Journal of antimicrobial chemotherapy - 1 Mar 2017

Kletenkov K, Hoffmann D, Böni J, Yerly S, Aubert V, Schöni-Affolter F, Struck D, Verheyen J, Klimkait T

Abstract excerpt

Background: HIV Gag mutations have been reported to confer PI drug resistance. However, clinical implications are still controversial and most current genotyping algorithms consider solely the protease gene for assessing PI resistance. Objectives: Our goal was to describe for HIV infections in Switzerland the potential role of the C-terminus of Gag (NC-p6) in PI resistance. We aimed to characterize...

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Share to Drug Resistance, Viral
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, gag

Share to HIV Infections

Share to HIV Protease

Share to HIV Protease Inhibitors

Share to Switzerland

Share to Treatment Failure

Source

Identifiers

PMID: 27999036
DOI: 10.1093/jac/dkw493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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