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Article

Role of Gag in HIV Resistance to Protease Inhibitors

5 Jul 2010

Abstract excerpt

Cleavage of Gag and Gag-Pol precursors by the viral protease is an essential step in the replication cycle of HIV. Protease inhibitors, which compete with natural cleavage sites, strongly impair viral infectivity and have proven to be highly valuable in the treatment of HIV-infected subjects. However, as with all other antiretroviral drugs, the clinical benefit of protease inhibitors can be compromised by...

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PMID: 21994687
DOI: 10.3390/v2071411

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