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Article

Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function.

Cancer research - 1 Oct 2008

Liao Yi-Chun, Shih Yi-Ping, Lo Su Hao

Abstract excerpt

Deleted in liver cancer-1 (DLC-1) is a RhoGTPase-activating protein (RhoGAP) domain containing tumor suppressor that is often down-regulated in various cancer types. Previously, we have shown that DLC-1 is recruited to focal adhesions by binding to the Src homology 2 domains of tensins and the focal adhesion localization is critical for the tumor suppression activity of DLC-1. To investigate whether mutations in...

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Identifiers

PMID: 18829524
DOI: 10.1158/0008-5472.CAN-08-2042
PMCID: PMC2597479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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