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Article

Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes.

Genetic epidemiology - 1 Dec 2012

Guan Weihua, Boehnke Michael, Pluzhnikov Anna, Cox Nancy J, Scott Laura J

Abstract excerpt

When planning resequencing studies for complex diseases, previous association and linkage studies can constrain the range of plausible genetic models for a given locus. Here, we explore the combinations of causal risk allele frequency (RAFC ) and genotype relative risk (GRRC ) consistent with no or limited evidence for affected sibling pair (ASP) linkage and strong evidence for case-control association. We find...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22865662
DOI: 10.1002/gepi.21668
PMCID: PMC3578091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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