Article
Prioritising Causal Genes at Type 2 Diabetes Risk Loci.
Current diabetes reports - 1 Sept 2017
Grotz Antje K, Gloyn Anna L, Thomsen Soren K
Abstract excerpt
PURPOSE OF REVIEW: Genome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from association signals through causal genes to functional understanding has so far been slow, hindering clinical translation. This review discusses the benefits and limitations of emerging, unbiased approaches for...
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