Article
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
Diabetes - 1 Jul 2009
Prokopenko Inga, Zeggini Eleftheria, Hanson Robert L, Mitchell Braxton D, Rayner N William, Akan Pelin, Baier Leslie, Das Swapan K, Elliott Katherine S, Fu Mao, Frayling Timothy M, Groves Christopher J, Gwilliam Rhian, Scott Laura J, Voight Benjamin F, Hattersley Andrew T, Hu Cheng, Morris Andrew D, Ng Maggie, Palmer Colin N A, Tello-Ruiz Marcela, Vaxillaire Martine, Wang Cong-Rong, Stein Lincoln, Chan Juliana, Jia Weiping, Froguel Philippe, Elbein Steven C, Deloukas Panos, Bogardus Clifton, Shuldiner Alan R, McCarthy Mark I
Abstract excerpt
OBJECTIVE: Linkage of the chromosome 1q21-25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal. RESEARCH DESIGN AND METHODS: In all, 5,290 single nucleotide polymorphisms (SNPs) were successfully genotyped in 3,179 type 2 diabetes case and...
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