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Article

Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2012

Horckmans Michael, Léon-Gómez Elvira, Robaye Bernard, Balligand Jean-Luc, Boeynaems Jean-Marie, Dessy Chantal, Communi Didier

Abstract excerpt

Nucleotides released within the heart under pathological conditions can be involved in cardioprotection or cardiac fibrosis through the activation purinergic P2Y(2) and P2Y(6) receptors, respectively. We previously demonstrated that adult P2Y(4)-null mice display a microcardia phenotype related to a cardiac angiogenic defect. To evaluate the functional consequences of this defect, we performed here a combination...

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Identifiers

PMID: 22865387
DOI: 10.1152/ajpheart.00256.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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