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A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease

8 Oct 2013

Abstract excerpt

AIM: The expression of Nppa (ANF) and Nppb (BNP) marks the chamber myocardium in the embryo, and both genes serve as early and accurate markers for hypertrophy and heart failure. Non-invasive visualization of Nppa-Nppb expression in living mice would enable to evaluate the disease state during the course of time in heart disease models. We sought to develop a method to assess the pattern and level of Nppa and...

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PMID: 24104878
DOI: 10.1093/cvr/cvt228

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