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Article

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells.

Pflugers Archiv : European journal of physiology - 1 Sept 2012

Cruz-Rangel Silvia, Gamba Gerardo, Ramos-Mandujano Gerardo, Pasantes-Morales Herminia

Abstract excerpt

The involvement of WNK3 (with no lysine [K] kinase) in cell volume regulation evoked by anisotonic conditions was investigated in two modified stable lines of HEK293 cells: WNK3+, overexpressing WNK3 and WNK3-KD expressing a kinase inactive by a punctual mutation (D294A) at the catalytic site. This different WNK3 functional expression modified intracellular Cl(-) concentration with the following profile:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22864523
DOI: 10.1007/s00424-012-1137-4

Genes

WNK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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