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Article

Purkinje cell loss and motor coordination defects in profilin1 mutant mice.

Neuroscience - 25 Oct 2012

Kullmann J A, Neumeyer A, Wickertsheim I, Böttcher R T, Costell M, Deitmer J W, Witke W, Friauf E, Rust M B

Abstract excerpt

Profilin1 is an actin monomer-binding protein, essential for cytoskeletal dynamics. Based on its broad expression in the brain and the localization at excitatory synapses (hippocampal CA3-CA1 synapse, cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse), an important role for profilin1 in brain development and synapse physiology has been postulated. We recently showed normal physiology of hippocampal...

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PMID: 22864186
DOI: 10.1016/j.neuroscience.2012.07.055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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