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Article

Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons.

EMBO reports - 23 Dec 2011

Kullmann Jan A, Neumeyer Alexander, Gurniak Christine B, Friauf Eckhard, Witke Walter, Rust Marco B

Abstract excerpt

Cerebellar granule neurons (CGNs) exploit Bergmann glia (BG) fibres for radial migration, and cell-cell contacts have a pivotal role in this process. Nevertheless, little is known about the mechanisms that control CGN-BG interaction. Here we demonstrate that the actin-binding protein profilin1 is essential for CGN-glial cell adhesion and radial migration. Profilin1 ablation from mouse brains leads to a cerebellar...

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Source

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Identifiers

PMID: 22081137
DOI: 10.1038/embor.2011.211
PMCID: PMC3246249

Genes

CGN
PFN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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