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Article

Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation

28 Oct 2015

Abstract excerpt

During the pachytene stage of meiosis in male mammals, the X and Y chromosomes are transcriptionally silenced by Meiotic Sex Chromosome Inactivation (MSCI). MSCI is conserved in therian mammals and is essential for normal male fertility. Transcriptomics approaches have demonstrated that in mice, most or all protein-coding genes on the X chromosome are subject to MSCI. However, it is unclear whether X-linked...

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PMID: 26509798
DOI: 10.1371/journal.pgen.1005461

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