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Article

Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).

The Journal of allergy and clinical immunology - 1 Apr 2013

Chew Gary Y J, Sinha Umang, Gatenby Paul A, DeMalmanche Theo, Adelstein Stephen, Garsia Roger, Hissaria Pravin, French Martyn A, Wilson Anastasia, Whittle Belinda, Kirkpatrick Philippa, Riminton D Sean, Fulcher David A, Cook Matthew C

Abstract excerpt

BACKGROUND: The 1858T allele of protein tyrosine phosphatase nonreceptor type 22 (PTPN22; R620W) exhibits one of the strongest and most consistent associations with sporadic autoimmune disease. Although autoimmunity is common in patients with primary antibody deficiency (PAD), it remains unknown...

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Source

Identifiers

PMID: 22857794
DOI: 10.1016/j.jaci.2012.06.023

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22857794-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).PMID 22857794Read ↗

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