The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22) gene predisposes to autoimmune Addison's disease.

doi:10.1111/j.1365-2265.2008.03380.x

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Article

The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22) gene predisposes to autoimmune Addison's disease.

Clinical endocrinology - 1 Mar 2009

Roycroft Matthew, Fichna Marta, McDonald David, Owen Kate, Zurawek Magdalena, Gryczyńska Maria, Januszkiewicz-Lewandowska Danuta, Fichna Piotr, Cordell Heather, Donaldson Peter, Nowak Jerzy, Pearce Simon

Abstract excerpt

OBJECTIVE: Previous studies of the association between autoimmune Addison's disease (AAD) and a nonsynonymous single nucleotide polymorphism (SNP) in the PTPN22 gene (C1858T, pR620W; SNP ID no. rs2476601) have shown conflicting results. We aimed to examine this association using additional cohorts of AAD subjects from the UK and Poland. DESIGN: DNA samples were obtained from UK and Polish AAD subjects (n = 251...

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Identifiers

PMID: 18710467
DOI: 10.1111/j.1365-2265.2008.03380.x

Genes

PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22) gene predisposes to autoimmune Addison's disease.PMID 18710467Read ↗

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