Article
The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors.
Journal of bacteriology - 1 Nov 2009
Syed Khalid Ali, Beyhan Sinem, Correa Nidia, Queen Jessica, Liu Jirong, Peng Fen, Satchell Karla J F, Yildiz Fitnat, Klose Karl E
Abstract excerpt
Vibrio cholerae is a motile bacterium responsible for the disease cholera, and motility has been hypothesized to be inversely regulated with virulence. We examined the transcription profiles of V. cholerae strains containing mutations in flagellar regulatory genes (rpoN, flrA, flrC, and fliA) by utilizing whole-genome microarrays. Results revealed that flagellar transcription is organized into a four-tiered...
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