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Article

Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.

Molecular pharmacology - 1 Nov 2012

Ponce-Balbuena Daniela, Rodríguez-Menchaca Aldo A, López-Izquierdo Angélica, Ferrer Tania, Kurata Harley T, Nichols Colin G, Sánchez-Chapula José A

Abstract excerpt

Chloroquine and related compounds can inhibit inwardly rectifying potassium channels by multiple potential mechanisms, including pore block and allosteric effects on channel gating. Motivated by reports that chloroquine inhibition of cardiac ATP-sensitive inward rectifier K(+) current (I(KATP)) is antifibrillatory in rabbit ventricle, we investigated the mechanism of chloroquine inhibition of ATP-sensitive...

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Identifiers

PMID: 22851715
DOI: 10.1124/mol.112.079152
PMCID: PMC3477226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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