Article
Molecular determinants of KATP channel inhibition by ATP.
The EMBO journal - 15 Jun 1998
Tucker S J, Gribble F M, Proks P, Trapp S, Ryder T J, Haug T, Reimann F, Ashcroft F M
Abstract excerpt
ATP-sensitive K+ (KATP) channels are both inhibited and activated by intracellular nucleotides, such as ATP and ADP. The inhibitory effects of nucleotides are mediated via the pore-forming subunit, Kir6.2, whereas the potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR. T...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Diphosphate
- Adenosine Monophosphate
- Adenosine Triphosphate
- Animals
- Female
- KATP Channels
- Mice
- Mutation
- Potassium Channel Blockers
- Potassium Channels
- Potassium Channels, Inwardly Rectifying