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Article

Molecular determinants of KATP channel inhibition by ATP.

The EMBO journal - 15 Jun 1998

Tucker S J, Gribble F M, Proks P, Trapp S, Ryder T J, Haug T, Reimann F, Ashcroft F M

Abstract excerpt

ATP-sensitive K+ (KATP) channels are both inhibited and activated by intracellular nucleotides, such as ATP and ADP. The inhibitory effects of nucleotides are mediated via the pore-forming subunit, Kir6.2, whereas the potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR. The stimulatory action of Mg-nucleotides complicates analysis of nucleotide inhibition of Kir6. 2/SUR1 channels. We...

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Identifiers

PMID: 9628866
DOI: 10.1093/emboj/17.12.3290
PMCID: PMC1170667

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