Article
Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker.
FEBS letters - 30 Jan 2004
Taddei Alessandro, Folli Chiara, Zegarra-Moran Olga, Fanen Pascale, Verkman A S, Galietta Luis J V
Abstract excerpt
The thiazolidinone CFTR(inh)-172 was identified recently as a potent and selective blocker of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. Here, we characterized the CFTR(inh)-172 inhibition mechanism by patch-clamp and short-circuit analysis using cells stably expressing wild-type and mutant CFTRs. CFTR(inh)-172 did not alter CFTR unitary conductance (8 pS), but reduced open...
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