Article
Mechanism of lonidamine inhibition of the CFTR chloride channel.
British journal of pharmacology - 1 Nov 2002
Gong Xiandi, Burbridge Susan M, Lewis Angie C, Wong Patrick Y D, Linsdell Paul
Abstract excerpt
1. The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is blocked by a broad range of organic anionic compounds. Here we investigate the effects of the indazole compound lonidamine on CFTR channels expressed in mammalian cell lines using patch clamp recording. 2. Application of lonidamine to the intracellular face of excised membrane patches caused a voltage-dependent block of CFTR...
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