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Article

Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.

The Journal of general physiology - 1 Oct 1992

Sheppard D N, Welsh M J

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel that is regulated by cAMP-dependent phosphorylation and by intracellular ATP. Intracellular ATP also regulates a class of K+ channels that have a distinct pharmacology: they are inhibited by sulfonylureas and activated by a novel class of drugs called K+ channel openers. In search of modulators of CFTR Cl- channels, we examined the...

Topics

Adenosine Triphosphate
Animals
Cells, Cultured
Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Glyburide
Humans
Ion Channels
Membrane Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Potassium Channels

Sulfonylurea Compounds

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1281220
DOI: 10.1085/jgp.100.4.573
PMCID: PMC2229110

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1281220-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.PMID 1281220Read ↗

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