Article
The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
British journal of pharmacology - 1 Apr 2010
de Boer T P, Nalos L, Stary A, Kok B, Houtman M J C, Antoons G, van Veen T A B, Beekman J D M, de Groot B L, Opthof T, Rook M B, Vos M A, van der Heyden M A G
Abstract excerpt
BACKGROUND AND PURPOSE: Pentamidine is a drug used in treatment of protozoal infections. Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias associated with QTc prolongation and U-wave alterations. This proarrhythmic effect was linked to inhibition of hERG traffi...
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