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Article

Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.

Cardiovascular research - 1 Mar 2011

Noujaim Sami F, Stuckey Jeanne A, Ponce-Balbuena Daniela, Ferrer-Villada Tania, López-Izquierdo Angelica, Pandit Sandeep V, Sánchez-Chapula José A, Jalife José

Abstract excerpt

AIMS: Chloroquine, an anti-malarial quinoline, is structurally similar to quinidine. Both drugs have been shown to block ion channels. We tested the hypothesis that chloroquine's mode of interaction with the vestibule of the cytoplasmic domain of the inward rectifier potassium channel Kir2.1 make...

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Source

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Identifiers

PMID: 21233253
DOI: 10.1093/cvr/cvr008
PMCID: PMC3039250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21233253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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