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Article

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Cell stem cell - 5 Feb 2010

Quyn Aaron J, Appleton Paul L, Carey Francis A, Steele Robert J C, Barker Nick, Clevers Hans, Ridgway Rachel A, Sansom Owen J, Näthke Inke S

Abstract excerpt

The importance of asymmetric divisions for stem cell function and maintenance is well established in the developing nervous system and the skin; however, its role in gut epithelium and its importance for tumorigenesis is still debated. We demonstrate alignment of mitotic spindles perpendicular to...

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Source

Identifiers

PMID: 20144789
DOI: 10.1016/j.stem.2009.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20144789-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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