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Article

In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population.

European journal of clinical pharmacology - 1 Jun 2010

Djordjevic Natasa, Carrillo Juan Antonio, Gervasini Guillermo, Jankovic Slobodan, Aklillu Eleni

Abstract excerpt

PURPOSE: The main aim of the study was to investigate the distribution of cytochrome P450 2A6 (CYP2A6) and xanthine oxidase (XO) enzyme activities in the Serbian population. Secondly, we tested the influence of genetics (CYP2A6 polymorphism), sex, and cigarette smoking on both enzymes. METHODS: One hundred forty healthy Serbian volunteers were genotyped for common CYP2A6 alleles. In 100 of them, CYP2A6 and XO...

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PMID: 20155256
DOI: 10.1007/s00228-010-0785-6

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