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Article

The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells.

Genome biology - 1 Jan 2007

Jørgensen Helle F, Azuara Véronique, Amoils Shannon, Spivakov Mikhail, Terry Anna, Nesterova Tatyana, Cobb Bradley S, Ramsahoye Bernard, Merkenschlager Matthias, Fisher Amanda G

Abstract excerpt

BACKGROUND: The time of locus replication during S-phase is tightly regulated and correlates with chromatin state. Embryonic stem (ES) cells have an unusual chromatin profile where many developmental regulator genes that are not yet expressed are marked by both active and repressive histone modifications. This poised or bivalent state is also characterized by locus replication in early S-phase in ES cells, while...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17705870
DOI: 10.1186/gb-2007-8-8-r169
PMCID: PMC2374999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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