Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

doi:10.1093/hmg/ddt336

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Article

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Human molecular genetics - 1 Dec 2013

Ansari Morad, McKeigue Paul M, Skerka Christine, Hayward Caroline, Rudan Igor, Vitart Veronique, Polasek Ozren, Armbrecht Ana-Maria, Yates John R W, Vatavuk Zoran, Bencic Goran, Kolcic Ivana, Oostra Ben A, Van Duijn Cornelia M, Campbell Susan, Stanton Chloe M, Huffman Jennifer, Shu Xinhua, Khan Jane C, Shahid Humma, Harding Simon P, Bishop Paul N, Deary Ian J, Moore Anthony T, Dhillon Baljean, Rudan Pavao, Zipfel Peter F, Sim Robert B, Hastie Nicholas D, Campbell Harry, Wright Alan F

Abstract excerpt

It is a longstanding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associated with age-related macular degeneration (AMD) than functional coding variants that directly influence the alternative complement pathway. The situation is complicated by tight genetic associations across the region, including the adjacent CFH-related genes CFHR3 and CFHR1, which may themselves...

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Identifiers

PMID: 23873044
DOI: 10.1093/hmg/ddt336
PMCID: PMC3820139

Genes

CFH
CFHR1
CFHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.PMID 23873044Read ↗

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