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Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis

29 Mar 2017

Abstract excerpt

OBJECTIVE: Vitamin D deficiency has been linked to increased risk of multiple sclerosis (MS) and poor outcome. However, the specific role that vitamin D plays in MS still remains unknown. In order to identify potential mechanisms underlying vitamin D effects in MS, we profiled epigenetic changes in vitamin D receptor (VDR) gene to identify genomic regulatory elements relevant to MS pathogenesis. METHODS: Human T...

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PMID: 28355272
DOI: 10.1371/journal.pone.0174726

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