Article
Type II secretion system of Pseudomonas aeruginosa: in vivo evidence of a significant role in death due to lung infection.
The Journal of infectious diseases - 15 May 2011
Jyot Jeevan, Balloy Viviane, Jouvion Gregory, Verma Amrisha, Touqui Lhousseine, Huerre Michel, Chignard Michel, Ramphal Reuben
Abstract excerpt
BACKGROUND: The role of toxins secreted by the type II secretion system (T2SS) of Pseudomonas aeruginosa during lung infection has been uncertain despite decades of research. METHODS: Using a model of pneumonia in Toll-like receptor (TLR) 2,4(-/-) mice, we reexamined the role of the T2SS system. Flagellin-deficient mutants of P. aeruginosa, with mutations in the T2SS and/or T3SS, were used to infect mice. Mice...
Topics
- Animals
- Bacterial Toxins
- Bronchoalveolar Lavage Fluid
- Flagellin
- Gene Expression Regulation, Bacterial
- Immunity, Innate
- Immunocompetence
- Lung
- Mice
- Mice, Knockout
- Mutation
- Pneumonia, Bacterial
- Pseudomonas Infections