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Article

Type II secretion system of Pseudomonas aeruginosa: in vivo evidence of a significant role in death due to lung infection.

The Journal of infectious diseases - 15 May 2011

Jyot Jeevan, Balloy Viviane, Jouvion Gregory, Verma Amrisha, Touqui Lhousseine, Huerre Michel, Chignard Michel, Ramphal Reuben

Abstract excerpt

BACKGROUND: The role of toxins secreted by the type II secretion system (T2SS) of Pseudomonas aeruginosa during lung infection has been uncertain despite decades of research. METHODS: Using a model of pneumonia in Toll-like receptor (TLR) 2,4(-/-) mice, we reexamined the role of the T2SS system. Flagellin-deficient mutants of P. aeruginosa, with mutations in the T2SS and/or T3SS, were used to infect mice. Mice...

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Identifiers

PMID: 21502078
DOI: 10.1093/infdis/jir045
PMCID: PMC3080898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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