Article
Role of ppGpp in Pseudomonas aeruginosa acute pulmonary infection and virulence regulation.
Microbiological research - 1 Nov 2016
Xu Xiaohui, Yu Hua, Zhang Di, Xiong Junzhi, Qiu Jing, Xin Rong, He Xiaomei, Sheng Halei, Cai Wenqiang, Jiang Lu, Zhang Kebin, Hu Xiaomei
Abstract excerpt
During infection, bacteria might generate adaptive responses to facilitate their survival and colonization in the host environment. The alarmone guanosine 5'-triphosphate-3'-diphosphate (ppGpp), the levels of which are regulated by the RelA and SpoT enzymes, plays a critical role in mediating bacterial adaptive responses and virulence. However, the mechanism by which ppGpp regulates virulence-associated traits in...
Topics
- A549 Cells
- Animals
- Bacterial Proteins
- Biofilms
- Disease Models, Animal
- Gene Deletion
- Guanosine Pentaphosphate
- Humans
- Male
- Mice
- Microbial Viability
- Phenotype
- Pneumonia, Bacterial
- Pseudomonas Infections