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Article

Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function.

PloS one - 1 Jan 2012

Gu Zhen, Liu Yahong, Zhang Yongjie, Jin Shulei, Chen Qi, Goltzman David, Karaplis Andrew, Miao Dengshun

Abstract excerpt

We assessed whether the nuclear localization sequences (NLS) and C terminus of parathyroid hormone-related protein (PTHrP) play critical roles in brain development and function. We used histology, immunohistochemistry, histomorphometry, Western blots and electrophysiological recordings to compare...

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Identifiers

PMID: 22844494
DOI: 10.1371/journal.pone.0041542
PMCID: PMC3402381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22844494-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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