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Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain‐to‐bone signaling pathway

24 Oct 2016

Abstract excerpt

Regulation of bone development, growth, and remodeling traditionally has been thought to depend on endocrine and autocrine/paracrine modulators. Recently, however, brain-derived signals have emerged as key regulators of bone metabolism, although their mechanisms of action have been poorly understood. We reveal the existence of an ancient parathyroid hormone (Pth)4 in zebrafish that was secondarily lost in the...

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PMID: 28148780
DOI: 10.1096/fj.201600815r

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